During 1978–80 a survey was conducted to ascertain the prevalence ofSalmonellain raccoons (Procyon lotor)in Indiana. The animals were live‐trapped and their feces and mesenteric lymph nodes cultured for salmonellae. Of the total 106 raccoons examined, 43 salmonellae isolations were made from 33 animals (33.1%). The mesenteric lymph nodes from 8 of 20 raccoons which were necropsied contained salmonellae. Twelve serotypes were identified. Two harbored 3 serotypes, while 7 others were colonized with 2 serotypes. Urban origin raccoons were 30.8%Salmonellapositive, while 34.7% of the rural raccoons yielded the pathogens. Among the adults, 29.6% were positive and 33.3% of the immature animals harbored salmonellae. The most frequently isolated organism wasS. typhimurium(35%) and its variant, Copenhagen. The antibiograms of theSalmonellaisolates were ascertained using 12 antimicrobials. Resistance to common antimicrobials used in veterinary practice was minimal.