A major structural abnormality in the renin gene of the spontaneously hypertensive rat
作者:
Nilesh Samani,
William Brammar,
John Swales,
期刊:
Journal of Hypertension
(OVID Available online 1989)
卷期:
Volume 7,
issue 4
页码: 249-254
ISSN:0263-6352
年代: 1989
出版商: OVID
关键词: Genetic hypertension in rats;renin gene;Southern blot analysis;cDNA/oligonucleotide probes;intron A;tandemly repeated sequence
数据来源: OVID
摘要:
The renin genes of the spontaneously hypertensive rat (SHR) and Wistar-Kyoto (WKY) rat were compared by Southern blotting using cDNA and oligonucleotide probes. A deletion of 650 base pairs was found in the first intron (intron A) of the SHR gene compared with the WKY gene. Our studies strongly suggest that this is due to a decrease in the number of copies of the tandemly repeated sequence present within intron A of the rat renin gene. In both SHR and WKY, this region of the gene was found to be different from that of the parent Wistar rat and those of other Wistar-based inbred strains. The functional significance of the abnormality and any role it may have in hypertension in the SHR remain to be determined.
点击下载:
PDF
(577KB)
返 回