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Increased Iron Absorption in Uroporphyrin-Treated Rats

 

作者: Gary A. Weaver,   Christopher A. Franck,   Mark D. Harris,   Theodore Peters,  

 

期刊: Digestion  （Karger Available online 1991）
卷期: Volume 49, issue 3  

页码: 151-155

 

ISSN:0012-2823

 

年代: 1991

 

DOI:10.1159/000200714

 

出版商: S. Karger AG

 

关键词: Porphyria cutanea tarda;Iron absorption;Uroporphyrin;Porphyrin

 

数据来源: Karger

 

摘要:

Rats were given 59Fe (28 µg) together with doses of 0, 2 and 200 µg of uroporphyrin III in paired observations. Absorption of 59Fe was determined by comparing whole body counts of the rats 30 min and 7 days after dosing. Prior treatment with 200 µg of uroporphyrin twice daily for 3 days was associated with significantly increased 59Fe absorption of 6.2% compared to the absorption of 4.6% without uroporphyrin (control) and 4.6% with a 2-µg dose (p < 0.

 

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