A Rise in Antineutrophil Cytoplasmic Antibody in a Patient with Systemic Vasculitis in Remission
作者:
Shinya Kaname,
Shunya Uchida,
Seiji Minoda,
Yoshihiro Arimura,
Toshihiko Nagasawa,
Shigetaka Asano,
Etsuro Ogata,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 68,
issue 3
页码: 380-384
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188405
出版商: S. Karger AG
关键词: Antineutrophil cytoplasmic antibody;Prednisolone;Cyclophosphamide;Mizoribine;Wegener’s granulomatosis;Necrotizing glomerulonephritis;Leukocytoclastic angiitis;Immunoblot
数据来源: Karger
摘要:
We report a 42-year-old man who showed alveolar hemorrhage and glomerulonephritis as well as episcleritis and skin rash. He had an extremely high titer of cytoplasm-staining antineutrophil cytoplasmic antibody (C-ANCA) and was diagnosed as having systemic vasculitis based on histological findings of kidney and skin biopsies. After immunosuppressive therapy clinical manifestations resolved within several weeks and C-ANCA titers commensurably declined. C-ANCA titers, however, increased again and remained high despite clinical remission. In general, there is a close relationship between ANCA titers and clinical activities in ANCA-associated diseases, but they displayed a large discrepancy in this patient. Indeed, the serum of the patient in remission contained the antibody against 29-kD neutrophil extracts which was detected by immunoblot analysis. These findings suggest that C-ANCA may not necessarily be, by itself, pathogenetic for the development of the vasculitis.
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