Scavenger receptor Bl and cholesterol trafficking
作者:
David Williams,
Margery Connelly,
Ryan Temel,
Snehasikta Swarnakar,
Michael Phillips,
Margarita de la Llera-Moya,
George Rothblat,
期刊:
Current Opinion in Lipidology
(OVID Available online 1999)
卷期:
Volume 10,
issue 4
页码: 329-340
ISSN:0957-9672
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
Scavenger receptor Bl (SR-BI) mediates the selective uptake of HDL cholesteryl ester into steroidogenic cells and the liver and is a major determinant of the plasma HDL concentration in the mouse. Recent studies indicate that SR-BI also alters the metabolism of apolipoprotein B-containing particles and influences the development of atherosclerosis in several animal models. These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
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