Recombinant RelaxinA Review of Pharmacology and Potential Therapeutic Use
作者:
Emma S. Gavino,
Daniel E. Furst,
期刊:
BioDrugs
(ADIS Available online 2001)
卷期:
Volume 15,
issue 9
页码: 609-614
ISSN:1173-8804
年代: 2001
出版商: ADIS
关键词: Labour induction;Relaxin, therapeutic use;Research and development;Sclerosis, treatment
数据来源: ADIS
摘要:
Use of recombinant relaxin in the treatment of systemic sclerosis (or scleroderma) has been explored and determined as ineffective. However, continued research has revealed that relaxin is not limited to its role as a hormone. Relaxin has also been shown to decrease collagen formation and secretion, increase collagenase production, influence renal vasodilation, increase vascular endothelial growth factor expression and angiogenesis, promote dilation of blood vessels, and inhibit release of histamine. Further studies to discover other potential uses of relaxin are well-justified.
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