Complement C6 and C7 Polymorphisms in Japanese Patients with Chronic Glomerulonephritis
作者:
Hiroaki Nishimukai,
Isao Nakanishi,
Yoshihiro Takeuchi,
Ryota Sumiyoshi,
Kenji Mizutani,
Nobutoshi Iida,
Takaaki Shinomiya,
期刊:
Human Heredity
(Karger Available online 1989)
卷期:
Volume 39,
issue 3
页码: 150-155
ISSN:0001-5652
年代: 1989
DOI:10.1159/000153851
出版商: S. Karger AG
关键词: Complement;C6;C7;Chronic glomerulonephritis;IgA nephropathy;Idiopathic membranous nephropathy;Minimal-change nephrotic syndrome
数据来源: Karger
摘要:
C6 and C7 types were studied in 158 Japanese patients with different types of chronic glomerulonephritis: 75 patients with IgA nephropathy (IgA-N); 49 patients with idiopathic membranous nephropathy (IMN), and 34 patients with minimal-change nephrotic syndrome (MCNS). There were significant differences in the C6 and C7 allele and phenotype frequencies between the patient groups and controls. A strong association was found between IgA-N and C7 5 phenotype (p < 0.001, RR = 12.71), and between MCNS and C7 5 phenotype (p < 0.001, RR = 14.20). A significant association between MCNS and C6 B2 phenotype (p < 0.05, RR = 2.42) was also found. In the IMN patient group, a significant association with C7 4 phenotype (p < 0.05, RR = 2.42) was observed. Thus, C6 and C7 phenotypes may be causative factors in the development of chronic glomerulonephritis.
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