Renal Transplantation in Systemic Lupus erythematosus
作者:
Nabil Yakub,
Richard B. Freeman,
Rufino C. Pabico,
期刊:
Nephron
(Karger Available online 1981)
卷期:
Volume 27,
issue 4-5
页码: 197-201
ISSN:1660-8151
年代: 1981
DOI:10.1159/000182053
出版商: S. Karger AG
关键词: SLE;Lupus nephritis graft;Recurrent disease;Immune-complex deposits;Anti-DNA antibody;Transplantation;renal allograft;Recurrent disease
数据来源: Karger
摘要:
3 patients with chronic renal failure due to lupus nephritis received kidney allografts from cadaver donors. Serological activity was present in 2 patients at the time of transplantation, and continued unabated despite intensive immunosuppressive therapy. Their allograft failed at 5 and 7 months after transplantation. Anti-DNA antibody in the allograft was found in 1 patient. The 3rd patient, with no serological activity at the time of transplantation, remained serologically negative, and her allograft functioned for 18 months. The persistence of serological activity in 1 patient, and the recovery of anti-DNA antibody from her allograft provide proof for the recurrence of lupus nephritis in the allograft.
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