Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia
作者:
LingQing,
LouMarjorie F.,
StraatsmaBradley R.,
HorwitzJoseph,
期刊:
Current Eye Research
(Taylor Available online 1993)
卷期:
Volume 12,
issue 5
页码: 433-437
ISSN:0271-3683
年代: 1993
DOI:10.3109/02713689309024625
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The distribution of glutathione-S-transferase (GST) activity was determined in frozen normal human lenses. The highest activity of GST was found in the peripheral and equatorial regions, whereas the lowest activity was found in the nucleus. Western blot showed that bothμandχisoenzymes of GST were present in human lenses. This result is similar to that found in rat lenses. In addition, GST activity was analyzed in 50 lens epithelia which were obtained during cataract surgery. Twenty-seven lens epithelia showed no activity. Statistically significant association was found between cortical and mixed cortical-nuclear cataract and loss of GST activity. No association was found between pure nuclear cataract and loss of epithelial GST activity.
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