&NA;This paper presents two cases of adenosquamous carcinoma of the colon and brings to 39 the total number documented in medical literature. The concurrent glandular and squamous differentiation of the tumor cells was demonstrated by immunocytochemistry and electron microscopy. Evaluation of the biologic characteristics of all the reported cases suggests that malignant squamous elements in colonic carcinomas behave more aggressively than their glandular counter‐parts. In contradistinction from the pure squamous‐cell carcinoma of the colon, adenosquamous carcinoma does not show the same predilection for the right colon.