Hemoglobin Diffusion Across a Venous WallAn Experimental Study
作者:
Gisela Skopp,
Lucia Pötsch,
Rainer Lutz,
Beate Ganßmann,
Rainer Mattern,
期刊:
The American Journal of Forensic Medicine and Pathology
(OVID Available online 1998)
卷期:
Volume 19,
issue 4
页码: 372-376
ISSN:0195-7910
年代: 1998
出版商: OVID
关键词: Hemoglobin;Chien-Valia diffusion chamber;Extravasation;Postmortem diffusion;Forensic toxicology
数据来源: OVID
摘要:
The aim of this study was to investigate the permeation behavior of a large molecule through a venous wall; hemoglobin was chosen as a model substance. In vitro experiments were performed using a Chien-Valia diffusion chamber. Postmortem, hemolyzed, and fresh nonhemolyzed blood samples were investigated as permeants. Vein patches from vena cava inferior and vena jugularis interna were used as diffusion barriers. Applying this technique, extravasation of hemoglobin was detectable. The portion of hemoglobin molecules passing through the vascular wall depended on time, vein type, and graduation of hemolysis. The passage of hemoglobin across the wall of a large vein suggests intravascular changes in drug concentrations from postmortem blood samples not to be restricted on the unbound portion of the particular drug.
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