Genetic epidemiology of coeliac disease
作者:
J. L. Tiwari,
H. Betuel,
L. Gebuhrer,
N. E. Morton,
D. C. Rao,
期刊:
Genetic Epidemiology
(WILEY Available online 1984)
卷期:
Volume 1,
issue 1
页码: 37-42
ISSN:0741-0395
年代: 1984
DOI:10.1002/gepi.1370010106
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Coeliac disease;segregation analysis;mixed model;linkage;HLA association;affected sib pairs
数据来源: WILEY
摘要:
AbstractSegregation analysis favors a gene additive on liability with a frequency of 0.022, which is nearly recessive on the penetrance scale. Less than one‐eighth of DR3 and DR7 haplotypes carry a determinant for coeliac disease. There is significant excess of DR3/7 heterozygotes among patients, indicating that the determinants are qualitatively different in DR3 and DR7 haplotypes. Linkage to HLA is highly significant (maximum lod score = 10.9). Evidence for recombination of 8% in males is attributed to residual errors in the model. We suggest an approach to a more precise mode
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