Synthesis and Antitumor Activity of “Pyran Copolymer”
作者:
GeorgeB. Butler,
期刊:
Journal of Macromolecular Science, Part C
(Taylor Available online 1982)
卷期:
Volume 22,
issue 1
页码: 89-130
ISSN:1532-1797
年代: 1982
DOI:10.1080/07366578208081059
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Many naturally occurring polyanionic materials are known, each of which possesses its own set of physiological properties. Recently, a variety of synthetic polyanions have become available, and their physiological properties have been compared with the naturally occurring polyanions. Probably the most widely investigated synthetic polyanion is the 1:2 regularly alternating cyclo-copolymer (DIVEMA) (Eq. 1) of divinyl ether (DVE) and maleic anhydride (MA), first discovered in these laboratories in 1951 [1], This material has been investigated extensively, both from the standpoint of its chemical structure [2] and its antitumor activity [3]. Although certain aspects of its structure remain to be determined [4], it has been shown to possess a wide spectrum of biological activity [5] and is an interferon inducer [3]. Many structural modifications of DIVEMA have been synthesized which also possess antitumor activity and interferon-inducing capability [6].
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