Statisticians are increasingly finding applications which require separate linear models for a response of interest and this response's variance. A crucial question then becomes what are reasonable experimental strategies which will allow the estimation of both of these functions. This paper pursues two distinct approaches: a one-step approach which, in the absence of any information about the process variance, initially assumes that the process variance is constant over the region of interest; and a one-step, semi-Bayesian approach which attempts to develop an appropriate experimental plan in light of prior information about the nature of the variance function. These two approaches are compared in a simulation study to illuminate their relative advantages and disadvantages. An example illustrates the proposed methodology.