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Quantitative Structure‐Activity Relationship Studies on Some Acyclouridine Derivatives Acting as Anti‐HIV‐1 Drugs

 

作者: Rajni Garg,   Alka Kurup,   S. P. Gupta,  

 

期刊: Quantitative Structure‐Activity Relationships  （WILEY Available online 1997）
卷期: Volume 16, issue 1  

页码: 20-24

 

ISSN:0931-8771

 

年代: 1997

 

DOI:10.1002/qsar.19970160104

 

出版商: WILEY‐VCH Verlag

 

关键词: Quantitative structure‐activity relationship;HIV‐1 inhibitors;HEPT derivatives

 

数据来源: WILEY

 

摘要:

AbstractThe anti‐HIV‐1 activity of some derivatives of 1‐[2‐hydroxyethoxy]‐6‐(phenylthio)thymine(HEPT) is analyzed in relation to their physicochemical and molecular properties. The activities of the compounds are found to be significantly correlated with hydrophobic constant π and the van der Waals volume Vw. The results are found to be useful in discussing the mechanism of drug‐recept

 

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