The sequences of two peptides from cataract lenses suggest they arise by deamidation
作者:
TakemotoL.,
EmmonsT.,
GranstromD.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 8
页码: 793-797
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999575
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Polyclonal antisera made against synthetic peptides corresponding to expected tryptic fragments of gamma crystallin have been used to screen tryptic digests of total proteins from cataractous versus normal human lenses. One of these antisera recognizes two peptides that were found in greater amounts from digests of cataractous lenses. These two peptides shared a common sequence that contained an aspartate residue in place of an expected asparagine, suggesting that increased deamidation of this residue had occurred in the human cataractous lensin vivo.
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