The Effect of Ethacrynic Acid on Perilymph Na and K
作者:
K.S. Wilson,
S.K. Juhn,
期刊:
ORL
(Karger Available online 1970)
卷期:
Volume 32,
issue 5
页码: 279-287
ISSN:0301-1569
年代: 1970
DOI:10.1159/000274948
出版商: S. Karger AG
关键词: Ototoxicity;Ethacrynic acid;Diuretics;Perilymph
数据来源: Karger
摘要:
A study of the effect of ethacrynic acid on guinea-pig blood, cerebrospinal fluid and perilymph Na and K is reported. After exposure to 50 mg/kg of ethacrynic acid administered over 48 h, the perilymph K, 1.6 h following the last injection, was found to be markedly elevated above control values (0.01 > P > 0.001). This change in K may result from ethacrynic acid inhibition of a membrane ATPase system. One speculation is that elhacrynic acid ototoxicity results from the inhibition of cochlear-duct membrane ATPase.
点击下载:
PDF
(1885KB)
返 回