Clinical Oncology and Chemical Thermodynamics
作者:
SeitzDavid E.,
PearceHomer L.,
期刊:
Cancer Investigation
(Taylor Available online 1990)
卷期:
Volume 8,
issue 2
页码: 233-235
ISSN:0735-7907
年代: 1990
DOI:10.3109/07357909009017569
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe development of oncolytic agents for cancer chemotherapy is often based on chance discovery and intensive structure modification. A mechanistic understanding of the essential biochemistry of many anticancer drugs remains elusive because of the biological complexity of drug-drug and drug-target interactions. The potential of computational science to analyze and quantify these interactions may provide a rational basis for drug modification and clinical trial design.
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