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Chronic Hemodialysis in the Anephric Goat

 

作者: John D. Bower,   Robert D. Holbert,   James E. Pearson,   Quintus Jones,   Roy Bengis,   W.O. Berndt,  

 

期刊: Nephron  （Karger Available online 1980）
卷期: Volume 25, issue 1  

页码: 34-39

 

ISSN:1660-8151

 

年代: 1980

 

DOI:10.1159/000181750

 

出版商: S. Karger AG

 

关键词: Nephrectomy;Hemodialysis;Spanish;brush goat;Anephric goat;Anephric animal model

 

数据来源: Karger

 

摘要:

The Spanish brush goat (Capra hiricus) was studied as an animal model for the anephric state. This rugged animal has a hardy appetite and offers ready blood access for dialysis and sampling. BUN, plasma creatinine and potassium could be brought to normal values by daily hemodialysis. Continual weight loss, severe anemia and some tendency for the development of hypertension were observed despite dialysis. Maintenance of a healthy rumen proved a continual challenge but was possible by hyperalimentation and vigorous dialysis immediately postnephrectomy.

 

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