Two rapid assay procedures based on high performance liquid chromatography (HPLC) and derivative ultraviolet (UV) spectrophotometry have been developed for the simultaneous determination of pindolol and clopamide in two component tablets. An HPLC assay with RP-18 column, of 250 × 4.6 mm ID as dimension and 10 μm silica particles, was used. The mobile phase consisted of water-methanol-acetonitrile (50–45–5) with pH of 3 and a flow rate of 1.5 ml min−1. Detection was at 264 nm with a band width of 10 nm. The derivative spectrophotometric procedure depends on the measurements of2D amplitude in methanol at 264 nm for pindolol and ▴1D amplitude of the delta absorption spectra (methanolic HCl -methanolic NaOH) at 249 nm for clopamide. For HPLC procedure the calibration graphs were linear in the ranges of 10–20 and 5–10 μg ml−1for pindolol and clopamide, respectively. For the derivative method, they were linear in the ranges of 10–26 and 10–20 μg ml−1for pindolol and clopamide, respectively. The calibration graphs showed a good linearity and obedience to Beer's law. Commercial tablets and laboratory-made mixtures containing both pindolol and clopamide in different proportions were assayed by the developed procedures. The results were of comparable accuracy as indicated by a statistical analysis of the data, using both t- and F-tests.