Von Willebrand Factor in the Rat Kidney: Its Localization and the Effects of Its in vivo Interaction with Specific Antibodies
作者:
Shogo Ito,
Kaoru Hirabayashi,
Neal Nielsen,
Yoshihiko Ueda,
Jan R. Brentjens,
Rijk O. Gans,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 66,
issue 2
页码: 200-207
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187801
出版商: S. Karger AG
关键词: Von Willebrand factor;Antibodies to endothelium;Factor VIII-related antigen
数据来源: Karger
摘要:
Antiendothelial cell antibodies and increased von Willebrand factor (vWF) levels are observed in many renal diseases. We studied renal morphology after administration of rabbit anti-human factor VIII-von Willebrand factor (FVIII-vWFc) γ-globulin (IgG) in rats. Isolated perfusion of normal rat kidney with the antibodies disclosed rabbit IgG along glomerular endothelium and in mesangial areas. Systemic administration resulted in an identical antibody distribution. C3 deposits and few electron dense deposits were transiently noted. After 1 week the mesangial deposition of rabbit IgG had increased significantly, most likely reflecting increased release of vWF by the endothelium. Thereafter, the deposits gradually relocated into mesangial stalk and into the glomerular vascular pole, and they had vanished after 6 weeks. Except for a mild influx of leukocytes, no renal injury occurred. In conclusion, although FVIII-vWFc antibodies cause mesangial immune deposits, antibodies against other endothelial antigens are apparently needed to inflict renal damage
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