Effects of cyclic nucleotide analogs on intraocular pressure and trauma-induced inflammation in the rabbit eye
作者:
BuschMichiel J. W. M.,
van OosterhoutEric J. G. M.,
HoyngPhilip F.J.,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 1
页码: 5-13
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209069162
出版商: Taylor&Francis
数据来源: Taylor
摘要:
In this study the effects of cell-permeable 8-bromo-cAMP and 8-bromo-cGMP on intraocular pressure (IOP) and puncture-induced inflammatory response were investigated. Both 8-bromo-cAMP and 8-Bromo-cGMP reduced IOP when given subconjunctivally, but not topically. Subconjunctival administration of 8-bromo-cAMP induced a moderate disruption of the blood-aqueous barrier (BAB); in addition, subconjunctival 8-bromo-cAMP, but not topical 8-bromo-cAMP or subconjunctival 8-bromo-cGMP, reduced the disruption of the BAB and elevation of the aqueous PGE2level after puncture trauma.It is concluded that the effects of 8-bromo-cAMP depend on the mode of administration, since this determines the concentration of 8-bromo-cAMP reached in the aqueous humor. It is suggested that 8-bromo-cAMP can partially suppress a slight inflammatory response by interference with the release of arachidonic acid from the tissues surrounding the aqueous humor.
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