Effect of Cyclophosphamide on Murine Nephrotoxic Nephritis
作者:
Yoji Kusuyama,
Toru Nishihara,
Eisei Gen,
Koji Saito,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 33,
issue 3
页码: 220-223
ISSN:1660-8151
年代: 1983
DOI:10.1159/000182946
出版商: S. Karger AG
关键词: Nephrotoxic nephritis;Mice;Cyclophosphamide
数据来源: Karger
摘要:
We studied the effect of cyclophosphamide (CPM) on development of severe glomerular lesions in a model of murine nephrotoxic nephritis (NTN). CPM treatment (300 mg/kg) before initiation of the first phase on NTN showed no host antibody depositions along the glomerular basement membrane, as revealed by immunofíuorescence; however, the histological study revealed no significant difference in the degree of renal damage between the control and the CPM-treated mice. Therefore, the severe glomerular lesions in murine NTN may be induced without antibody response to nephrotoxin, in the glomerulus
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