Change in common carotid artery diameter, distensibility and compliance in subjects with a recent history of impaired glucose tolerancea 3‐year follow‐up study
作者:
Robert van Dijk,
Giel Nijpels,
Jos Twisk,
Mieke Steyn,
Jacqueline Dekker,
Robert Heine,
Ab Donker,
Coen Stehouwer,
期刊:
Journal of Hypertension
(OVID Available online 2000)
卷期:
Volume 18,
issue 3
页码: 293-300
ISSN:0263-6352
年代: 2000
出版商: OVID
关键词: common carotid artery distensibility;common carotid artery compliance;impaired glucose tolerance;blood pressure
数据来源: OVID
摘要:
ObjectiveTo assess the development of common carotid artery properties (diameter, distensibility and compliance) in a cohort of 140 subjects (mean age 65.8 years, SD 7.5 years) originally diagnosed as impaired glucose tolerant in a population-based study, and to explore determinants of changes observed.DesignAn observational, longitudinal study over a 3-year-period.MethodsVessel wall movement detector system based on ultrasonography, linear generalized estimating equations.ResultsCarotid artery diameter rose from 6.87–7.02 mm (+ 2.2%,P< 0.001). Distensibility decreased from 11.8 to 10.9 × 10−3kPa−1(−8.3%,P= 0.009). Compliance decreased from 0.44–0.43 mm2kPa−1(P= 0.17). Changes in blood pressure level were negatively associated with changes in distensibility and compliance. Baseline fasting glucose levels were positively associated with changes in diameter, while fasting insulin levels were negatively associated with changes in distensibility and compliance in men, but not in women.ConclusionsIn subjects with a recent history of impaired glucose tolerance, we observed an increase in carotid artery diameter and a decrease in distensibility. Change in blood pressure level and baseline fasting glucose and HbA1c levels were positively related to the increase in diameter. In men, but not in women, baseline fasting insulin levels were associated with an acceleration of these changes.
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