AbstractPolyurethanes with saccharide moieties in their repeating units (8and9) were prepared by polyaddition of methyl α‐ and β‐D‐glucofuranosidurono‐6,3‐lactones (3α and3β, respectively) and 1,4:3,6‐dianhydro‐D‐glucitol (4) with hexamethylene diisocyanate (5a) and methyl (S)‐2,6‐diisocyanatohexanoate (5b), which was derived from L‐lysine, inN,N‐dimethylformamide at 25°C using dibutyltin dilaurate as a catalyst. Their properties were compared with those of the polyurethanes (6and7) prepared from D‐glucaro‐1,4:6,3‐dilactone (1) and D‐mannaro‐1,4:6,3‐dilactone (2), respectively, in our previous work. Hydrolyzability of the polyurethanes containing1, 2, or3αunits in buffer solutions was found to be higher than th