Spectrophotometric Determination of the Antihistamines, Carbinoxamine Maleate and Doxylamine Succinate, in anN-Cetylpyridinium Chloride Micellar Medium
作者:
Li Monferrer-Pons,
J.S. Esteve-Romero,
G. Ramis-Ramos,
M.C. Garcia-Alvarez-Coque,
期刊:
Analytical Letters
(Taylor Available online 1996)
卷期:
Volume 29,
issue 8
页码: 1399-1413
ISSN:0003-2719
年代: 1996
DOI:10.1080/00032719608001490
出版商: Taylor & Francis Group
关键词: Carbinoxamine maleate;Doxylamine succinate;König reaction;Micellar medium;N-Cetylpyridinium chloride
数据来源: Taylor
摘要:
The pyridine antihistamines carbinoxamine maleate and doxylamine succinate were derivatized by hydrolysis with cyanogen bromide and coupling with aniline to form a polymethine dye, and determined by colorimetry. In a micellar cationic medium ofN-cetylpyridinium chloride (NCPC), the reaction times were reduced and the sensitivities improved. In 0.1 M NCPC the apparent molar absorptivities of the derivatives were 5,900 and 3,500 M−1cm−1, and the limits of detection (as 3s) were 8.6x10−7M and 1.7x106M, for carbinoxamine and doxylamine, respectively. The sensitivity was enhanced in a three- to six-fold factor with respect to a non-micellar medium. The reproducibility was 0.8% for 1.6x10−4M carbinoxamine, and 1.8% for 1.3x10−4M doxylamine. The procedure was applied to the evaluation of the drugs in pharmaceutical preparations.
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