Endothelin-Like Immunoreactivity in the Aqueous Humour and in Conditioned Medium from Cultured Ciliary Epithelial Cells
作者:
LeppleAlbrecht,
BeckerMarion,
StahlFrank,
BerweckSusanne,
HensenJohannes,
NoskeWalter,
EichhornMichael,
WiederholtMichael,
期刊:
Current Eye Research
(Taylor Available online 1992)
卷期:
Volume 11,
issue 11
页码: 1041-1046
ISSN:0271-3683
年代: 1992
DOI:10.3109/02713689209015075
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Endothelin-like immunoreactivity was detected in human (15.6±2.7 pg/ml) and bovine (11.1±0.98 pg/ml) aqueous humour of the eye. These concentrations are 2-3 times higher than the corresponding plasma levels. Cultured human nonpigmented ciliary epithelial cells released endothelin-like immunoreactivity with a maximum of 2.1±0.32 pg/(cm248 h). The release was stimulated by fetal calf serum, thrombin, carbachol and phorbol ester and blocked by cycloheximide. Immunocytochemistry showed cytoplasmic staining of cultured human nonpigmented ciliary epithelial cells for endothelin-1. Endothelin-1 was shown to induce contractions in isolated human ciliary muscle by isometric force measurements. Endothelin in the aqueous humour may play a role in the regulation of intraocular pressure.
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