Purpose.To report a patient with consecutive Descemet's membrane (DM) detachments after successive phacoemulsification, review other reported patients with bilateral DM detachments, and explore the possibility of anatomic predisposition to DM detachment in some patients.Methods.Our patient's course was reviewed along with the reported experience with three other patients with bilateral DM detachments.Results.No clear underlying etiology of DM detachment was found in our patient or any of the other three reported patients reviewed.Conclusions.Some patients may be anatomically predisposed to DM detachment possibly because of an abnormality in the fibrillary stromal attachment to DM. Early postoperative surgical intervention often leads to satisfactory visual results.