The induction of the α‐1‐adrenoceptor signal transduction system on human melanocytes
作者:
Karin U. Schallreuter,
Christa Körner,
Mark R. Pittelkow,
Norma N. Swanson,
Michael L. G. Gardner,
期刊:
Experimental Dermatology
(WILEY Available online 1996)
卷期:
Volume 5,
issue 1
页码: 20-23
ISSN:0906-6705
年代: 1996
DOI:10.1111/j.1600-0625.1996.tb00088.x
出版商: Blackwell Publishing Ltd
关键词: α‐1‐adrenoceptors;melanocytes
数据来源: WILEY
摘要:
AbstractHuman melanocytes established in MCDB‐153 culture medium do not express α1‐, β1‐, β‐2 adrenoceptors without extracellular stimulation. The addition of 50×10−9M norepinephrine to the medium causes a time‐dependent induction of α‐1‐adrenoceptors with 4.278 receptors/melanocyte after 24 h. Under the same experimental conditions, the dendricity of melanocytes as well as melanogenesis was unaffected over 60 h. Since keralinocytes hold the full capacity for catecholamine biosynthesis but melanocytes lack this system, the secretion of catecholamines from keratinocytes appears to be of critical importance to the α‐1‐adrenoceptor in melanocytes, underlining the symbiosis of both ce
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