Anti-Cardiac Ryanodine Receptor Antibodies in Thymoma-Associated Myasthenia Gravis
作者:
MyglandÅse,
BjørnOle,
MatreRoald,
AarliJohan A.,
GilhusNils Erik,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 17,
issue 4
页码: 327-331
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409010673
出版商: Taylor&Francis
关键词: Myasthenia gravis;thymoma;ryanodine receptor;cardiac;autoantibody
数据来源: Taylor
摘要:
Sera from myasthenia gravis (MG) patients with thymoma were examined in Western blot for the presence of antibodies to proteins in the sarcoplasmic reticulum (SR) of cardiac muscle. Fourteen of 30 MG thymoma sera had IgG antibodies to a protein with the same electrophoretic mobility as cardiac muscle ryanodine receptor (RyR). Anti-cardiac RyR antibodies were not detected in any of the 45 sera from MG patients without thymoma. The same 14 MG thymoma sera, but none of the others, bound to RyR from skeletal muscle as well. Neutralization experiments showed that the anti-RyR antibodies in MG patient cross-reacted with cardiac and skeletal muscle RyR. Since skeletal and cardiac muscle RyRs are antigenically different, our findings may indicate that autoantibodies to RyR in MG originate by sensitization to a peptide shared by cardiac and skeletal muscle RyR, rather than to the complete native RyR.
点击下载:
PDF (523KB)
返 回