DYNAMIC CHANGES IN PLASMA INACTIVE RENIN LEVELS IN BARTTER'S SYNDROME AFTER ADMINISTRATION OF CAPTOPRIL AND ANGIOTENSIN II
作者:
Hiroyuki Nagai,
Masato Matsunaga,
Kazuya Ogawa,
Chun Ho Pak,
Kazuro Kanatsu,
Akira Hara,
Tsuyoshi Kono,
Chuichi Kawai,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1986)
卷期:
Volume 13,
issue 1
页码: 69-75
ISSN:0305-1870
年代: 1986
DOI:10.1111/j.1440-1681.1986.tb00317.x
出版商: Blackwell Publishing Ltd
关键词: active renin;angiotensin II;Bartter's syndrome;captopril;inactive renin.
数据来源: WILEY
摘要:
SUMMARY1. Changes in plasma active and inactive renin concentration (ARC and IRC) after captopril administration and angiotensin II (AII) infusion were studied in six patients with Bartter's syndrome.2. A single oral dose of captopril (8‐25 mg) lowered the blood pressure and increased both ARC and IRC. AII infusion elevated blood pressure, suppressed ARC and increased IRC.3. In this syndrome of high renin levels, infused AII appeared to increase inactive renin secretion by reducing its conversion to active renin. On the other hand, an acute fall in AII levels and/or renal perfusion pressure by captopril increased both active and inactive renin. This indicates that the increase in the secretion of inactive renin, stimulated by captopril, might exceed any increase in its conversion to active renin in patients with Bartter's syndrome, in whom the production of renin is accelerated, and conversion of inactive renin to active renin probably already operates near its maximu
点击下载:
PDF
(363KB)
返 回