Plasma viraemia in seronegative HIV‐1-infected individuals
作者:
Fabrizio Ensoli,
Valeria Fiorelli,
Ivano Mezzaroma,
Giampiero D'Offizi,
Luana Rainaldi,
Giuseppe Luzi,
Massimo Fiorilli,
Fernando Aiuti,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 10
页码: 1195-1200
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: AIDS;polymerase chain reaction;HIV-1 viraemia;seronegative infection.
数据来源: OVID
摘要:
It has been reported that the period of latency between HIV-1 infection and the production of antibodies against the virus is sometimes prolonged for >6 months. However, the data supporting this are still controversial and it is not known whether these individuals are actually infectious, especially through body fluids. We have performed a prospective study of 65 high-risk HIV-1-antibody-negative individuals who were followed-up for a period of at least 1 year. Twelve of these individuals were shown by polymerase chain reaction (PCR) to be carriers of HIV-1 proviral sequences. The virus was isolated from lymphocytes in five out of 10 PCR-positive subjects and from cell-free plasma in two. Our data indicate that in some cases delayed seroconversions may be associated with productive infection, suggesting that mechanism(s) other than viral latency may be responsible for the absence of antibody responses to HIV-1 proteins.
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