Model for cooperative control of positional information inDrosophilaby bicoid and maternal hunchback
作者:
John Reinitz,
Eric Mjolsness,
David H. Sharp,
期刊:
Journal of Experimental Zoology
(WILEY Available online 1995)
卷期:
Volume 271,
issue 1
页码: 47-56
ISSN:0022-104X
年代: 1995
DOI:10.1002/jez.1402710106
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe blastoderm of the fruit flyDrosophila melanogasteris unusually well suited for analysis of fundamental questions in animal development. One such question is how genes specify the positional information which determines the developmental pathways (fate) of cells at appropriate spatial locations. In this paper we propose a dynamical model of gene regulation which explicitly describes how positional information is used in the blastoderm. The model is applied to analyze important experimental findings on the dependence of cell fate on the concentration of the Bicoid morphogen. The model shows that positional information in the presumptive middle body is cooperatively determined by maternal products of thebicoidandhunchbackgenes. © 1995 Wiley‐Liss, I
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