Intracellular dCTP/ARA-CTP Ratio and the Cytotoxic Effect of ARA-C
作者:
KawasakiHajime,
KuwabaraHiroshi,
HoriHiroki,
HigashigawaMasamune,
OhkuboToshiki,
SakuraiMinoru,
期刊:
Cancer Investigation
(Taylor Available online 1991)
卷期:
Volume 9,
issue 4
页码: 409-413
ISSN:0735-7907
年代: 1991
DOI:10.3109/07357909109084638
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractIn this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.
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