Pathogenetic Mechanisms of Exercise Induced Asthma and the Refractory Period
作者:
Nick G. Belcher,
Steve O'Hickey,
Jonathan P. Arm,
Tak H. Lee,
期刊:
Pediatrics International
(WILEY Available online 1987)
卷期:
Volume 29,
issue 5
页码: 706-709
ISSN:1328-8067
年代: 1987
DOI:10.1111/j.1442-200X.1987.tb00365.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractExercise is a powerful stimulus to the development of asthma. In most asthmatic subjects the airways obstruction recovers spontaneously within 60 minutes, but in some subjects there is more prolonged airflow obstruction which requires bronchodilator treatment. Approximately 40–50% of subjects with EIA will show a refractory period of 2–4 hours after an initial exercise task, during which time an identical exercise task will evoke significantly less (%lt;50%) bronchoconstriction. In some patients, particularly children, EIA will be followed 3 to 9 hours later by a further episode of bronchospasm, termed the late asthmatic response. There remains considerable debate about the pathogenesis of EIA the refractory period and the late asthmatic respo
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