A corn‐small grain cropping sequence resulted in a greater total grain yield than corn or small grain alone or grain sorghum double cropped with small grain. Drought restricted yield responses to N, P and K in non‐irrigated plots but under irrigation grain yield for each cropping sequence was directly related to fertilizer applied. All fertilizer treatments increased soil acidity. Phosphorus and K applied at 26 and 50 kg/ha, respectively for each crop in the sequence maintained P and K levels in the soil. After three years, the high rate of fertilizer (87 and 166 kg/ha of P and K, respectively) resulted in greater soil P and K values than the low rate of fertilizer.