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Growth Hormone and the Immune Response to Bacterial Infection

 

作者: Hideaki Saito,   Tomomi Inoue,   Kazuhiko Fukatsu,   Lin Ming-Tsan,   Tuyoshi Inaba,   Ryoji Fukushima,   Tetsuichiro Muto,  

 

期刊: Hormone Research in Paediatrics  （Karger Available online 1996）
卷期: Volume 45, issue 1-2  

页码: 50-54

 

ISSN:1663-2818

 

年代: 1996

 

DOI:10.1159/000184759

 

出版商: S. Karger AG

 

关键词: Immunity;Phagocytosis;Priming;Insulin-like growth factor 1;Host defense

 

数据来源: Karger

 

摘要:

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1), especially the former, have immunoregulatory effects in addition to anabolic effects. The hormones may act to protect the host from lethal bacterial infection by promoting the maturation of myeloid cells, stimulating phagocyte migration, priming phagocytes for the production of superoxide anions and cytokines, and enhancing opsonic activity. GH administration may be beneficial for the prevention, as well as treatment, of severe sepsis in critical illness.

 

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