Epithelial Mediated Wound Contraction in Experimental Wounds—The Purse‐string Effect
作者:
PAUL BAUR,
DONALD PARKS,
J. HUDSON,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1984)
卷期:
Volume 24,
issue 8
页码: 713-720
ISSN:0022-5282
年代: 1984
出版商: OVID
数据来源: OVID
摘要:
Wound contraction, a process whereby wound edges are drawn together, is thought to be mediated by the myofibroblast cell population. However, experimental wounds may close as much as 25% (surface area) before the onset of fibroplasia which is marked by the migration of fibroblasts and myofibroblasts into the wound bed 2 to 3 days after injury. This early phase of wound closure appears to be mediated by a contractile force produced by a circumferentially arranged band of fusiform-shaped epidermal cells situated in the wound margin. Cytoplasmic microfilaments in the epidermal cells, similar in size and configuration to actin filaments and/or tonofilaments, are found to be aligned with the long axis of the constitutive cells comprising the contractile band. The data suggest that contraction in experimental wounds is promoted by at least two distinct cell-mediated contractile events: an initial although brief phase effected by cells of the epidermis followed by an extended phase of soft connective tissue contraction produced vis à vis the myofibroblasts in the dermis.
点击下载:
PDF
(3417KB)
返 回