Severe thrombotic tendency associated with a type I plasminogen deficiency
作者:
Frank W. G. Leebeek,
Eduard A. R. Knot,
Jan Wouter Ten Cate,
Daan W. Traas,
期刊:
American Journal of Hematology
(WILEY Available online 1989)
卷期:
Volume 30,
issue 1
页码: 32-35
ISSN:0361-8609
年代: 1989
DOI:10.1002/ajh.2830300107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: fibrinolysis;deep vein thrombosis;hypoplasminogenemia;DDAVP
数据来源: WILEY
摘要:
AbstractWe report a 45‐year‐old female patient with recurrent spontaneous deep vein thrombosis associated with an isolated hypoplasminogenemia (plasminogen activity and antigen level of 42% and 37%, respectively). The plasminogen molecule was normal as demonstrated by a normal activation by tissue plasminogen activator, electrophoretic mobility on crossed immunoelectrophoresis, molecular weight, and binding to lysine sepharose. All other hemostatic parameters predisposing to recurrent thrombosis were normal. A stimulation test with desmopressin acetate (DDAVP) showed a normal plasma rise of both tissue plasminogen activator and factor VIIIR:WF. This isolated plasminogen deficiency apparently is due to a decreased synthesis of a normal plasminogen molecule and is associated with a severe thrombotic tende
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