Ultralow doses of yasopressin in the management of diabetes insipidus
作者:
P. CHANSON,
C. JEDYNAK,
G. DABROWSKI,
J. ROHAN,
A. BOUCHAMA,
P. ROHAN-CHABOT,
P. LOIRAT,
期刊:
Critical Care Medicine
(OVID Available online 1987)
卷期:
Volume 15,
issue 1
页码: 44-46
ISSN:0090-3493
年代: 1987
出版商: OVID
数据来源: OVID
摘要:
Management of postoperative diabetes insipidus (DI) frequently requires intermittent treatment with multiple subcutaneous injections of pituitrin or vasopressin, in doses averaging 20 IU/24 h. Use of a syringe pump for a continuous infusion of ultralow doses of pituitrin produced uniform, constant, and sustained reduction of urinary output, thus facilitating regular fluid replacement. Twelve patients with postoperative DI received iv pituitrin at a dose of 1.6 ± 0.26 mIU/kg·h (1 to 2 IU/24 h). The antidiuretic effect began at the third hour of treatment, peaked by the sixth hour (diuresis of 37 ml/h, specific gravity of 1.018 ± 0.002), and was sustained throughout infusion. Polyuria recurred 3 h after the infusion was discontinued; this rapid reversibility is highly advantageous when excessive fluid intake causes overhydration. Pressor effects were not observed during the treatment period.
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