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Genetic Polymorphisms Influencing Therapy and Susceptibility to Rejection in Organ Allograft Recipients

 

作者: Francesca Poli,   Giuseppe Piccolo,   Mario Scalamogna,  

 

期刊: BioDrugs  (ADIS Available online 2002)
卷期: Volume 16, issue 1  

页码: 11-17

 

ISSN:1173-8804

 

年代: 2002

 

出版商: ADIS

 

关键词: Genetic polymorphism;Immunosuppressants, pharmacodynamics;Transplant rejection

 

数据来源: ADIS

 

摘要:

Solid organ transplantation during the past 30 years has developed from an experimental procedure into routine clinical practice. The current repertoire of immunosuppressive agents has made a major contribution to transplant survival; however, problems in different areas still need to be overcome.Several gene polymorphisms are supposed to influence immunosuppressive therapy and susceptibility to rejection. Therefore, a priority of transplant biologists is to estimate individual patient risk and to characterise the genetic profile of patients in need of a transplant in order to optimise the use of a scarce resource such as organs from cadaver donors, and to avoid serious drug-induced adverse effects. Polymorphisms in genes encoding tumour necrosis factor-α (TNFα), interleukin (IL)-6, IL-10, interferon-γ (IFNγ), transforming growth factor-β (TGFβ) and thiopurine S-methyltransferase (TPMT) can have significant effects on an individual’s risk of rejection, as well as their ability to tolerate immunosuppressive therapy. Genotyping of known polymorphisms in these genes may in the future contribute to our ability to individualise immunosuppressive therapy in organ transplant recipients.

 

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