Severe pathological changes of parabrachial nucleus in Alzheimer's disease
作者:
Josef Parvizi,
Gary Van Hoesen,
Antonio Damasio,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 18
页码: 4151-4154
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;Degenerative diseases;Autonomic nervous system;Brain stem;Mortality;Parabrachial nucleus
数据来源: OVID
摘要:
IN the first of a series of studies aimed at mapping brain stem pathological changes in patients with Alzheimer's disease (AD), we report a new finding regarding the parabrachial nucleus (PBN), a unit of paramount importance in the relay and integration of visceral and nociceptive information as well as in homeostatic control. The brains of 20 patients with AD were surveyed. The PBN contained pervasive neuropathological changes in 100% of the brains from those with early-onset dementia and in 80% from those with late-onset dementia. These changes were entirely absent in all 10 normal controls. The pathological changes of PBN, would cause autonomic dysfunction in patients with AD and perhaps contribute to the disproportionate mortality encountered in these patients.
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