Epidemiologic study of insecticide exposures, obesity, and risk of bladder cancer in household dogs
作者:
LawrenceT. Glickman,
FrancesS. Schofer,
LindaJ. McKee,
JohnS. Reif,
MichaelH. Goldschmidt,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 28,
issue 4
页码: 407-414
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531360
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A case‐control study of household dogs was conducted to determine if exposure to sidestream cigarette smoke and chemicals in the home, use of topical insecticides, and obesity are associated with the occurrence of bladder cancer. Information was obtained by interview from owners of 59 dogs with transitional‐cell carcinoma of the bladder and 71 age‐ and breed size‐matched control dogs with other chronic diseases or neoplasms. Bladder cancer risk was unrelated to sidestream cigarette smoke and household chemical exposures. Risk was significantly increased by topical insecticide use (OR =1.6 for 1–2 applications per year and OR = 3.5 for >2 applications per year; X2trend;P=.008). This risk was enhanced in overweight or obese dogs. Further studies of this canine model may facilitate identification of specific carcinogens present in insecticides commonly used on pet animals and in the environment.
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