Background.Infection withNocardiaspecies is an increasingly recognized complication of solid organ transplantation.Nocardia asteroidesaccounts for most transplant-related nocardiosis, whileNocardia brasiliensisrarely causes infection in organ transplant recipients.Methods.We describe a case of disseminated infection withN brasiliensisin a single-lung transplant recipient who also had concomitant infections with viral and fungal organisms.Results.Although the mortality rate is high in immunocompromised patients with disseminatedNocardiainfection, our patient responded favorably to prolonged antimicrobial therapy.Conclusions.This case illustrates thatN brasiliensis,likeN asteroides,produces pulmonary disease and dissemination in solid organ transplant recipients, and demonstrates the utility of prolonged treatment with trimethoprim-sulfamethoxazole inNocardiainfections.