Metabolic rate in the right amygdala predicts negative affect in depressed patients
作者:
Heather Abercrombie,
Stacey Schaefer,
Christine Larson,
Terrence Oakes,
Kristen Lindgren,
James Holden,
Scott Perlman,
Patrick Turski,
Dean Krahn,
Ruth Benca,
Richard Davidson,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 14
页码: 3301-3307
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Affect;Affective disorders;Affective symptoms;Amygdaloid body;Brain metabolism;Depressive disorder;Emotions;Psychophysiology;Tomography, emission-computed;Thalamus
数据来源: OVID
摘要:
THE role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMRglu) was measured with [18F]fluorodeoxyglucose positron emission tomography (PET) in two samples of subjects using two different PET cameras. The samples consisted of 10 and 17 medication-free depressives and 11 and 13 controls, respectively. Using coregistration of PET and magnetic resonance images, regions were individually delineated for the amygdala and thalamus, the latter of which was used as a control region. Within the depressed groups, right amygdalar rCMRgluwas positively correlated with negative affect. Thalamic rCMRgluwas not related to negative affect, and amygdalar rCMRgluaccounted for a significant portion of variance in depressives' negative affect scores over and above the contribution of thalamic rCMRglu.
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