As the prognosis for Hodgkin's disease improves, clients face many issues related to quality of life. Of paramount concern to women with Hodgkin's disease are issues related to sexual and reproductive health. Since nurses are likely professionals to whom patients may direct such concerns, it is imperative for them to be knowledgeable about the effects of Hodgkin's disease and its treatment on these areas. Part I of this paper discusses areas of concern for women with Hodgkin's disease, including sexual health, quality of relationships, fertility, and potential parenting concerns. In Part II, the PLISSIT model of sexual counseling is presented as a basis for assessment and intervention. A data base and nursing care plan, based on this model, are presented. Clinical applications for the nurse and suggestions for research are included.