Effect of Changes in Ventricular Relaxation on Early Diastolic Coronary Blood Flow in Canine Hearts
作者:
Leslie Domalik-Wawrzynski,
Wm. Powell,
Luis Guerrero,
Igor Palacios,
期刊:
Circulation Research
(OVID Available online 1987)
卷期:
Volume 61,
issue 5
页码: 747-756
ISSN:0009-7330
年代: 1987
出版商: OVID
关键词: reperfusion;hypothermia;verapamil;myocardial relaxation;early diastolic coronary blood flow
数据来源: OVID
摘要:
Since the gradient between aortic pressure and left ventricular diastolic pressure is a major determinant of coronary blood flow, a change in left ventricular relaxation by its effect on early diastole could diminish early diastolic coronary flow. Two interventions that resulted in impaired left ventricular relaxation, hypothermia, and reperfusion following a left anterior descending coronary artery occlusion were studied to evaluate whether there were associated changes in coronary blood flow. With both interventions, there was a significant prolongation of left ventricular relaxation (p<0.01) accompanied by a significant decrease in early diastolic coronary blood flow (p<0.01). Verapamil did not have a significant effect on these hemodynamic changes during hypothermia. However, verapamil significantly blunted the effects of reperfusion following ischemia on ventricular relaxation (p<0.002) and early diastolic coronary blood flow (p<0.01). Thus, impaired left ventricular relaxation has an adverse impact on early diastolic coronary blood flow, which, under the condition of reperfusion following regional myocardial ischemia, can be alleviated with calcium channel blockade. (Circulation Research 1987;61:747-756)
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