AbstractWith the purpose of obtaining animalarial prodrugs, oxidized starch derivatives with antimalarials were prepared. Imines with one drug, sulfonamide or pyrimidine, were synthesized and submitted to usual spectrometric analysis, IR. UV and1H NMR. With these analysis it was concluded that the following compounds were obtained: derivatives of sulfamethoxazole(ML7), sulfisoxazole(ML8) sulfameter(ML11) and trimethoprim(ML13). Only sulfameter derivative was curative in 100% of mice infected with Plasmodium berghei at 50 mg/weight kg dosis.