By using the product operator technique, analytical description of multipulse NMR experiments can be made. 2D DEPT J-resolved NMR spectroscopy is obtained by combining DEPT and 2D J-resolved NMR spectroscopy. In this study, the analytical description of heteronuclear 2D DEPT J-resolved NMR spectroscopy for a weakly coupledISn(I= 1/2,S= 1,n= 1,2,3) spin system is presented and experimental suggestions for13C 2D DEPT J-resolved NMR spectroscopy of deuterated molecules have been made.