Participation of the Renin System in Treatment-Resistant Hypertension as Measured by Acute Blockade of the Angiotensin Converting Enzyme
作者:
Michael A. Weber,
Jan I.M. Drayer,
Richard T. Priest,
Teh-Chung J. Chen,
期刊:
American Journal of Nephrology
(Karger Available online 1982)
卷期:
Volume 2,
issue 1
页码: 6-11
ISSN:0250-8095
年代: 1982
DOI:10.1159/000166575
出版商: S. Karger AG
关键词: Renin;Captopril;Converting enzyme inhibitor;Refractory hypertension
数据来源: Karger
摘要:
The acute blood pressure response to the angiotensin converting enzyme inhibitor, captopril, was used to measure participation of the renin-angiotensin system in treatment-resistant hypertension. By 2 h after a single 25-mg oral captopril dose in patients still receiving a diuretic-vasodilator-beta-blocker combination, systolic and diastolic blood pressures had fallen significantly; the decrease in diastolic pressure correlated with the control (immediately pre-captopril) plasma renin activity (r = 0.64, p < 0.001). Apart from its possible contribution to the underlying hypertension, this captopri-identified renin component may have reflected diuretic and vasodilator-induced renin stimulation that could not adequately be prevented by the renin-lowering properties of the beta-blocker. Captopril, and perhaps other specific antirenin drugs, therefore, may be valuable adjuncts to treatment in patients with hypertension refractory to conventional therapy.
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